A stakeholder survey was conducted from April through June of 2018 to understand stakeholders perceptions and challenges about cropping systems and weed management in Brazil. The dominant crops managed by survey respondents were soybean (73%) and corn (66%). Approximately 75% of survey respondents have grown or managed annual cropping systems with two to three crops cultivated per year in succession. Eighteen percent of respondents manage only irrigated cropping systems, and over 60% of respondents adopt no-till as a standard practice. According to respondents, the top five troublesome weed species in Brazilian cropping systems are horseweed (asthmaweed, Canadian horseweed and tall fleabane), sourgrass, morningglory, goosegrass, and dayflower (Asiatic dayflower and Benghal dayflower). Among the nine species documented to have evolved resistance to glyphosate in Brazil, horseweed and sourgrass were reported as the most concerning weeds. Other than glyphosate, 31 and 78% of respondents manage acetyl-CoA carboxylase (ACCase)-inhibitor and/or acetolactate synthase (ALS)-inhibitor resistant weeds, respectively. Besides herbicides, 45% of respondents use mechanical, and 75% use cultural (e.g., no-till, crop rotation/succession) weed control strategies. Sixty-one percent of survey respondents adopt cover crops to some extent to suppress weeds and improve soil chemical and physical properties. Nearly 60% of survey respondents intend to adopt the dicamba or 2,4-D resistant crops when available. Results may help practitioners, academics, industry and policy makers better understand the bad and the good of current cropping systems and weed management practices adopted in Brazil, and adjust research, education, technologies priorities and needs moving forward.